Potensi antitumor dari beberapa spons laut asal teluk Manado
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Abstract
Screening of antitumor for the extract and fraction from the marine sponges of
Manado Gulf, Aaptos sp., Acervochalina sp., Gelliodes sp., Theonella sp., and orange
boring sponge have been done by use P388 murine leukemia cell. Activity test result
showed IC50 of the extract and fraction from Aaptos sp were: MeOH extract 5938
ng/mL and BuOH extract 125000 ng/mL; Acervochalina sp: EtOH extract 125000
ng/mL, PE extract 125000 ng/mL, EtOAc extract 4251 ng/mL, BuOH extract
125000 ng/mL; Gelliodes sp: EtOH extract 125000 ng/mL; Theonella sp: EtOH
extract 125000 ng/mL, PE extract 9282 ng/mL, EtOAc extract 3273 ng/mL, BuOH
extract 125000 ng/mL; orange boring sponge: MeOH extract 1422 ng/mL. Based on
the IC50 value, it could be concluded that MeOH extract of Aaptos sp., EtOAc extract
of boring sponge could be a sources for cytotoxic compounds.
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